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h1: CSER-bake off node
p: The National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI) have initiated a Clinical Sequencing Exploratory Research (CSER) program to support multidimensional research in this area. CSER conducts bake-off experiments where overlapping set of variants are curated by leading clinical-genetics testing centers. The evidence tags populated by curators and generated assertions are systematically compared with the assertion generated by pathogenicity calculator, a key component of ClinGenKB infrastructure.
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h1: CSER Bake off summary
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Allele	site1	site2	site3	site4	site5	site6	site7	site8	site9
CA090928	Likely Pathogenic	Pathogenic	Likely Pathogenic	Pathogenic	Pathogenic	Pathogenic	Pathogenic	Pathogenic	Likely Pathogenic
CA090905		Benign		Benign					Benign
CA090899	Likely Pathogenic	Likely Pathogenic					Likely Pathogenic
CA000387	Pathogenic	Pathogenic					Likely Pathogenic
CA008761		Uncertain Significance		Uncertain Significance					Benign
CA008351		Benign					Likely Benign		Benign
CA090925	Uncertain Significance	Uncertain Significance				Uncertain Significance
CA090945		Likely Pathogenic				Pathogenic		Uncertain Significance
CA012936		Pathogenic	Uncertain Significance					Likely Pathogenic
CA009809		Likely Benign	Benign		Uncertain Significance
CA090921		Pathogenic		Benign					Uncertain Significance
CA090917		Pathogenic	Pathogenic		Pathogenic
CA090913	Likely Pathogenic		Pathogenic			Likely Pathogenic
CA090943			Likely Pathogenic				Likely Pathogenic		Likely Pathogenic
CA021744	Uncertain Significance		Likely Pathogenic			Likely Pathogenic
CA090947	Uncertain Significance		Uncertain Significance			Uncertain Significance
CA090941		Uncertain Significance	Uncertain Significance	Likely Pathogenic
CA090914			Uncertain Significance			Likely Benign		Uncertain Significance
CA008448		Uncertain Significance	Uncertain Significance		Uncertain Significance
CA090939	Uncertain Significance	Uncertain Significance	Uncertain Significance	Uncertain Significance	Uncertain Significance	Uncertain Significance	Likely Pathogenic	Uncertain Significance	Uncertain Significance
CA002038		Likely Benign	Benign		Uncertain Significance
CA090940		Uncertain Significance	Uncertain Significance		Uncertain Significance
CA000204		Pathogenic			Pathogenic				Likely Pathogenic
CA090898			Likely Pathogenic		Pathogenic				Pathogenic
CA009190	Uncertain Significance					Uncertain Significance			Uncertain Significance
CA090942						Uncertain Significance		Likely Pathogenic	Uncertain Significance
CA090888		Uncertain Significance		Uncertain Significance					Uncertain Significance
CA021817		Benign					Uncertain Significance		Likely Benign
CA020822	Uncertain Significance	Likely Benign	Likely Benign	Likely Benign	Likely Benign	Likely Benign	Uncertain Significance	Likely Benign	Likely Benign
CA013604	Uncertain Significance						Likely Benign		Uncertain Significance
CA024433	Uncertain Significance						Likely Benign		Likely Benign
CA016212			Benign					Benign	Likely Benign
CA024057		Uncertain Significance			Uncertain Significance				Uncertain Significance
CA011761		Pathogenic			Pathogenic		Likely Pathogenic
CA090884	Pathogenic	Pathogenic	Pathogenic	Pathogenic	Likely Pathogenic	Pathogenic	Likely Pathogenic	Uncertain Significance	Uncertain Significance
CA090903			Likely Pathogenic		Pathogenic		Likely Pathogenic
CA090920	Uncertain Significance					Uncertain Significance	Likely Pathogenic
CA090948		Likely Pathogenic		Pathogenic			Likely Pathogenic
CA090900				Benign			Benign		Benign
CA019451			Uncertain Significance				Likely Benign	Uncertain Significance
CA090909			Likely Benign		Uncertain Significance		Uncertain Significance
CA090886	Benign		Uncertain Significance				Uncertain Significance
CA090887	Uncertain Significance					Uncertain Significance	Uncertain Significance
CA090937						Pathogenic	Pathogenic	Pathogenic
CA090952	Pathogenic	Pathogenic			Pathogenic
CA090931	Likely Pathogenic	Uncertain Significance		Uncertain Significance
CA090946	Uncertain Significance	Uncertain Significance		Uncertain Significance
CA090938	Uncertain Significance						Likely Pathogenic		Likely Pathogenic
CA090918	Uncertain Significance		Benign					Benign
CA090885				Uncertain Significance			Uncertain Significance		Uncertain Significance
CA090926	Benign					Uncertain Significance		Uncertain Significance
CA090910	Pathogenic			Likely Pathogenic					Likely Pathogenic
CA090901	Pathogenic	Pathogenic		Pathogenic
CA090924	Likely Benign	Uncertain Significance	Uncertain Significance	Uncertain Significance	Uncertain Significance	Likely Benign	Uncertain Significance	Uncertain Significance	Uncertain Significance
CA015432	Benign			Uncertain Significance					Likely Benign
CA090908	Benign		Uncertain Significance					Likely Benign
CA090927		Likely Pathogenic		Likely Pathogenic	Pathogenic
"":http://genboree.org/java-bin/clingenpV1.9.jsp?conf=csersite&ca=		Uncertain Significance		Likely Pathogenic	Pathogenic		Uncertain Significance
CA090897	Pathogenic				Pathogenic	Pathogenic
CA090889	Likely Pathogenic	Uncertain Significance	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic
CA090929					Likely Pathogenic	Likely Pathogenic		Likely Pathogenic
CA090933			Uncertain Significance	Uncertain Significance	Uncertain Significance
CA017597			Benign		Pathogenic			Benign
CA090912			Likely Pathogenic		Pathogenic			Uncertain Significance
CA090894	-
CA090893	Uncertain Significance
CA010235	Uncertain Significance				Likely Benign		Uncertain Significance
CA090907					Benign	Benign		Benign
CA090950		Uncertain Significance			Uncertain Significance	Likely Benign
CA012232	Uncertain Significance			Uncertain Significance	Benign	Uncertain Significance		Likely Benign
CA090915					Uncertain Significance	Uncertain Significance		Uncertain Significance
CA022880		Pathogenic		Pathogenic		Likely Pathogenic
CA021883			Pathogenic		Uncertain Significance	Likely Pathogenic
CA090919	Likely Pathogenic	Likely Pathogenic	Uncertain Significance	Likely Pathogenic	Likely Pathogenic	Uncertain Significance	Likely Pathogenic	Likely Pathogenic	Uncertain Significance
CA090906						Uncertain Significance	Likely Pathogenic		Likely Pathogenic
CA090953						Likely Pathogenic	Pathogenic		Likely Pathogenic
CA090904				Pathogenic		Likely Pathogenic			Likely Pathogenic
CA090896	Uncertain Significance					Uncertain Significance	Uncertain Significance
CA090930			Likely Pathogenic			Uncertain Significance		Uncertain Significance
CA090922		Likely Pathogenic			Pathogenic			Uncertain Significance
CA090902			Uncertain Significance			Uncertain Significance		Uncertain Significance
CA004451	Pathogenic						Likely Pathogenic	Pathogenic
CA090916	Uncertain Significance			Uncertain Significance				Benign
CA090944		Uncertain Significance			Uncertain Significance			Uncertain Significance
CA090890			Pathogenic		Pathogenic			Pathogenic
CA090911	Uncertain Significance					Uncertain Significance		Likely Pathogenic
CA006474	Likely Benign	Uncertain Significance	Benign	Likely Benign	Uncertain Significance	Benign	Benign	Benign	Uncertain Significance
CA026468							Uncertain Significance	Likely Benign	Benign
CA017654	Likely Pathogenic						Uncertain Significance	Pathogenic
CA090923				Pathogenic				Likely Pathogenic	Uncertain Significance
CA004058				Uncertain Significance			Uncertain Significance		Uncertain Significance
CA024311				Pathogenic		Likely Pathogenic			Pathogenic
CA090951			Pathogenic	Uncertain Significance	Pathogenic
CA090949				Uncertain Significance				Likely Benign	Uncertain Significance
CA090936				Uncertain Significance		Uncertain Significance		Likely Pathogenic
CA090935				Pathogenic			Likely Pathogenic		Pathogenic
CA090895			Uncertain Significance	Uncertain Significance				Likely Benign
CA090932	Likely Pathogenic	Likely Pathogenic	Pathogenic	Pathogenic	Pathogenic	Likely Pathogenic	Likely Pathogenic	Likely Pathogenic	Pathogenic
CA090891				Benign				Benign	Benign

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