{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA135098",
  "communityStandardTitle": [
    "NM_004333.6(BRAF):c.1786G>T (p.Gly596Cys)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=53981[alleleid]",
        "alleleId": 53981,
        "preferredName": "NM_004333.6(BRAF):c.1786G>T (p.Gly596Cys)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/44814",
        "RCV": [
          "RCV000037933",
          "RCV001813335",
          "RCV002513489"
        ],
        "variationId": 44814
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr7:g.140453149C>A?assembly=hg19",
        "id": "chr7:g.140453149C>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr7:g.140753349C>A?assembly=hg38",
        "id": "chr7:g.140753349C>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/121913361",
        "rs": 121913361
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/7-140753349-C-A?dataset=gnomad_r4",
        "id": "7-140753349-C-A",
        "variant": "7:140753349 C / A"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 140753349,
          "referenceAllele": "C",
          "start": 140753348
        }
      ],
      "hgvs": [
        "NC_000007.14:g.140753349C>A",
        "CM000669.2:g.140753349C>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000055"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 140453149,
          "referenceAllele": "C",
          "start": 140453148
        }
      ],
      "hgvs": [
        "NC_000007.13:g.140453149C>A",
        "CM000669.1:g.140453149C>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000031"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 140099618,
          "referenceAllele": "C",
          "start": 140099617
        }
      ],
      "hgvs": [
        "NC_000007.12:g.140099618C>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000007"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 176416,
          "referenceAllele": "G",
          "start": 176415
        }
      ],
      "hgvs": [
        "NG_007873.3:g.176416G>T",
        "LRG_299:g.176416G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000682"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2012,
          "referenceAllele": "G",
          "start": 2011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000646891.2:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000493543.1:p.Gly596Cys",
        "hgvsWellDefined": "ENSP00000493543.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS906449",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000646891.2:c.1786G>T"
          },
          "RefSeq": {
            "hgvs": "NM_004333.6:c.1786G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000493543.1:p.Gly596Cys"
          },
          "RefSeq": {
            "hgvs": "NP_004324.2:p.Gly596Cys"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1935,
          "referenceAllele": "G",
          "start": 1934
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000288602.11:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000288602.7:p.Gly636Cys",
        "hgvsWellDefined": "ENSP00000288602.7:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743952"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 456,
          "referenceAllele": "G",
          "start": 455
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000479537.6:c.456G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS757306"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1893,
          "referenceAllele": "G",
          "start": 1892
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000496384.7:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000419060.2:p.Gly596Cys",
        "hgvsWellDefined": "ENSP00000419060.2:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS757830"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1872,
          "referenceAllele": "G",
          "start": 1871
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000497784.2:c.*1236G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000420119.2:n.*1236G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS757877"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1776,
          "referenceAllele": "G",
          "start": 1775
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000642228.1:c.*864G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000493678.1:n.*864G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS766628"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1258,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 1258,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000642875.1:n.1259-3931G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS766965"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2176,
          "referenceAllele": "G",
          "start": 2175
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000644120.1:n.2176G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS767644"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 882,
          "referenceAllele": "G",
          "start": 881
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000644650.1:c.882G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS767921"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2668,
          "referenceAllele": "G",
          "start": 2667
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000644905.1:n.2668G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS768066"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2132,
          "referenceAllele": "G",
          "start": 2131
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000644969.2:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000496776.1:p.Gly636Cys",
        "hgvsWellDefined": "ENSP00000496776.1:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS768098",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000644969.2:c.1906G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001374258.1:c.1906G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000496776.1:p.Gly636Cys"
          },
          "RefSeq": {
            "hgvs": "NP_001361187.1:p.Gly636Cys"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2122,
          "referenceAllele": "G",
          "start": 2121
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000646730.1:c.*362G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000494784.1:n.*362G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769037"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2011,
          "referenceAllele": "G",
          "start": 2010
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000646891.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000493543.1:p.Gly596Cys",
        "hgvsWellDefined": "ENSP00000493543.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769120"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 737,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 737,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000647434.1:c.738-3931G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000495132.1:n.738-3931G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769410"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1847,
          "referenceAllele": "G",
          "start": 1846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000288602.10:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000288602.6:p.Gly596Cys",
        "hgvsWellDefined": "ENSP00000288602.6:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS253526"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 70,
          "referenceAllele": "G",
          "start": 69
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000479537.5:c.70G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000418033.1:p.Gly24Cys",
        "hgvsWellDefined": "ENSP00000418033.1:p.Gly24Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS319895"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 609,
          "referenceAllele": "G",
          "start": 608
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000496384.6:c.609G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS332865"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1821,
          "referenceAllele": "G",
          "start": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "ENST00000497784.1:c.1821G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000420119.1:n.1821G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS333935"
    },
    {
      "@id": "http://reg.genome.network/allele/PA135100",
      "coordinates": [
        {
          "allele": "T",
          "end": 1847,
          "referenceAllele": "G",
          "start": 1846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_004333.4:c.1786G>T",
        "LRG_299t1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_004324.2:p.Gly596Cys",
        "hgvsWellDefined": "NP_004324.2:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS029502"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_005250045.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_005250102.1:p.Gly596Cys",
        "hgvsWellDefined": "XP_005250102.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059048"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_005250046.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_005250103.1:p.Gly596Cys",
        "hgvsWellDefined": "XP_005250103.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS059049"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_011516529.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514831.1:p.Gly596Cys",
        "hgvsWellDefined": "XP_011514831.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083730"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1702,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 1702,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_011516530.1:c.1695-3931G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514832.1:n.1695-3931G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083731"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_242190.1:n.1794G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS116222"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_927520.1:n.1794G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123925"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1794,
          "referenceAllele": "G",
          "start": 1793
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_927521.1:n.1794G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123926"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1702,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 1702,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_927522.1:n.1703-3931G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123927"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1702,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 1702,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_927523.1:n.1703-3931G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS123928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827883493",
      "coordinates": [
        {
          "allele": "T",
          "end": 2011,
          "referenceAllele": "G",
          "start": 2010
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001354609.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341538.1:p.Gly596Cys",
        "hgvsWellDefined": "NP_001341538.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS522553"
    },
    {
      "@id": "http://reg.genome.network/allele/PA135100",
      "coordinates": [
        {
          "allele": "T",
          "end": 2011,
          "referenceAllele": "G",
          "start": 2010
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_004333.5:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_004324.2:p.Gly596Cys",
        "hgvsWellDefined": "NP_004324.2:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525199"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2884,
          "referenceAllele": "G",
          "start": 2883
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NR_148928.1:n.2884G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS531377"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1914,
          "referenceAllele": "G",
          "start": 1913
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_017012558.1:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016868047.1:p.Gly636Cys",
        "hgvsWellDefined": "XP_016868047.1:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS566138"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1914,
          "referenceAllele": "G",
          "start": 1913
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XM_017012559.1:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016868048.1:p.Gly636Cys",
        "hgvsWellDefined": "XP_016868048.1:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS566139"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1914,
          "referenceAllele": "G",
          "start": 1913
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_001744857.1:n.1914G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS593501"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1822,
          "endIntronDirection": "-",
          "endIntronOffset": 3930,
          "referenceAllele": "G",
          "start": 1822,
          "startIntronDirection": "-",
          "startIntronOffset": 3931
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "XR_001744858.1:n.1823-3931G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS593502"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827883493",
      "coordinates": [
        {
          "allele": "T",
          "end": 2012,
          "referenceAllele": "G",
          "start": 2011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001354609.2:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001341538.1:p.Gly596Cys",
        "hgvsWellDefined": "NP_001341538.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690253"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828475014",
      "coordinates": [
        {
          "allele": "T",
          "end": 2132,
          "referenceAllele": "G",
          "start": 2131
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001374244.1:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001361173.1:p.Gly636Cys",
        "hgvsWellDefined": "NP_001361173.1:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693184"
    },
    {
      "@id": "http://reg.genome.network/allele/PA1139743294",
      "coordinates": [
        {
          "allele": "T",
          "end": 2132,
          "referenceAllele": "G",
          "start": 2131
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001374258.1:c.1906G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001361187.1:p.Gly636Cys",
        "hgvsWellDefined": "NP_001361187.1:p.Gly636Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS693190",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000644969.2:c.1906G>T"
          },
          "RefSeq": {
            "hgvs": "NM_001374258.1:c.1906G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000496776.1:p.Gly636Cys"
          },
          "RefSeq": {
            "hgvs": "NP_001361187.1:p.Gly636Cys"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA135100",
      "coordinates": [
        {
          "allele": "T",
          "end": 2012,
          "referenceAllele": "G",
          "start": 2011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_004333.6:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_004324.2:p.Gly596Cys",
        "hgvsWellDefined": "NP_004324.2:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696110",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000646891.2:c.1786G>T"
          },
          "RefSeq": {
            "hgvs": "NM_004333.6:c.1786G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000493543.1:p.Gly596Cys"
          },
          "RefSeq": {
            "hgvs": "NP_004324.2:p.Gly596Cys"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828775289",
      "coordinates": [
        {
          "allele": "T",
          "end": 2021,
          "referenceAllele": "G",
          "start": 2020
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378467.1:c.1795G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365396.1:p.Gly599Cys",
        "hgvsWellDefined": "NP_001365396.1:p.Gly599Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721717"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828775997",
      "coordinates": [
        {
          "allele": "T",
          "end": 2012,
          "referenceAllele": "G",
          "start": 2011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378468.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365397.1:p.Gly596Cys",
        "hgvsWellDefined": "NP_001365397.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721718"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828776654",
      "coordinates": [
        {
          "allele": "T",
          "end": 1946,
          "referenceAllele": "G",
          "start": 1945
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378469.1:c.1720G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365398.1:p.Gly574Cys",
        "hgvsWellDefined": "NP_001365398.1:p.Gly574Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721719"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828777330",
      "coordinates": [
        {
          "allele": "T",
          "end": 1910,
          "referenceAllele": "G",
          "start": 1909
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378470.1:c.1684G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365399.1:p.Gly562Cys",
        "hgvsWellDefined": "NP_001365399.1:p.Gly562Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721720"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828778002",
      "coordinates": [
        {
          "allele": "T",
          "end": 1901,
          "referenceAllele": "G",
          "start": 1900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378471.1:c.1675G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365400.1:p.Gly559Cys",
        "hgvsWellDefined": "NP_001365400.1:p.Gly559Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721721"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828778613",
      "coordinates": [
        {
          "allele": "T",
          "end": 1731,
          "referenceAllele": "G",
          "start": 1730
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378472.1:c.1630G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365401.1:p.Gly544Cys",
        "hgvsWellDefined": "NP_001365401.1:p.Gly544Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721722"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828779216",
      "coordinates": [
        {
          "allele": "T",
          "end": 1731,
          "referenceAllele": "G",
          "start": 1730
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378473.1:c.1630G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365402.1:p.Gly544Cys",
        "hgvsWellDefined": "NP_001365402.1:p.Gly544Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721723"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828779930",
      "coordinates": [
        {
          "allele": "T",
          "end": 2012,
          "referenceAllele": "G",
          "start": 2011
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378474.1:c.1786G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365403.1:p.Gly596Cys",
        "hgvsWellDefined": "NP_001365403.1:p.Gly596Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721724"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828780534",
      "coordinates": [
        {
          "allele": "T",
          "end": 1748,
          "referenceAllele": "G",
          "start": 1747
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378475.1:c.1522G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365404.1:p.Gly508Cys",
        "hgvsWellDefined": "NP_001365404.1:p.Gly508Cys"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721725"
    }
  ],
  "type": "nucleotide"
}